TPSB2 is a protein coding gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
Caractéristiques techniques
| Marque | Invitrogen |
|---|
| Réf. B-LABO | BL-RE-093392 |
|---|
| Réf. fabricant | 18537964 |
|---|
| Numéro d’adhésion | AV011504; EC 3.4.21; EC 3.4.21.59; mast cell protease 6; mast cell tryptase beta II; mast cell tryptase beta III; Mcp6; Mcp-6; Mcpt6; MMCP-6; rMCP-6; testicular tissue protein Li 163; TPS2; TPS2tryptase beta-2; Tpsb2; tryptase beta 2; tryptase beta 2 (gene/pseudogene); tryptase beta II; tryptase beta III; tryptase beta-2; Tryptase II; tryptase III; Tryptase-2; tryptaseB; tryptaseC; Tryptase-C |
|---|
| Plage de dosage | 0.84 to 200 ng/mL |
|---|
| Sensibilité du dosage | 0.84 ng/mL |
|---|
| Conjugué | Biotin |
|---|
| Type de produit | ELISA |
|---|
| Type d’échantillon | Serum |
|---|
| À utiliser avec (équipement) | Colorimetric Microplate Reader |
|---|
| Identification génétique (Entrez) | P21845 |
|---|
| Symbole de gène(s) | Tpsb2 |
|---|
| Coefficient de variation inter-dosage | <12% |
|---|
| Coefficient de variation intra-dosage | <10% |
|---|
| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
|---|
| Marqueur ou colorant | HRP |
|---|
| Quantité | 10 x 96 Tests |
|---|
| État réglementaire | Research Use Only |
|---|
| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
|---|
| Conditions de stockage | 2°C to 8°C |
|---|
| Cible | TPSB2 |
|---|
| Heure du test | 1 hr 20 min |
|---|
| Durée totale du dosage | 4 hr 45 min |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
