Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C (1) and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. IL-17Rh1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.
Caractéristiques techniques
| Marque | Invitrogen |
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| Réf. B-LABO | BL-RE-093791 |
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| Réf. fabricant | 18587864 |
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| Numéro d’adhésion | CRL4; cytokine receptor CRL4; cytokine receptor-like 4; ecotropic viral integration site 27; Evi27; IL-17 receptor B; IL-17 receptor homolog 1; IL-17 B; IL-17 B receptor; IL17BR; IL-17 ER; IL17RB; IL-17 RB; IL17RH1; IL-17 Rh1; IL-20; interleukin 17 receptor B; interleukin 17 receptor homolog 1; interleukin 17 B receptor; Interleukin-17 receptor B; interleukin-17 B receptor; MGC138900; MGC138901; MGC5245; UNQ2501/PRO19612; ZCYTO7 |
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| Plage de dosage | 0.2 to 50 ng/mL |
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| Sensibilité du dosage | 0.2 ng/mL |
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| Conjugué | Biotin |
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| Type de produit | ELISA |
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| Type d’échantillon | Plasma |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Identification génétique (Entrez) | Q9JIP3 |
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| Symbole de gène(s) | IL17RB |
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| Coefficient de variation inter-dosage | <12% |
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| Coefficient de variation intra-dosage | <10% |
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| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
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| Marqueur ou colorant | HRP |
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| Quantité | 10 x 96 Tests |
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| État réglementaire | Research Use Only |
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| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
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| Conditions de stockage | 2°C to 8°C |
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| Cible | IL17RB |
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| Heure du test | 1 hr 20 min |
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| Durée totale du dosage | 4 hr 45 min |
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