Mouse HGFR/MET quantitates mouse HGFR/MET in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse HGFR/MET.
MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Caractéristiques techniques
| Réf. B-LABO | BL-RE-094032 |
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| Réf. fabricant | 18517924 |
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| Numéro d’adhésion | AI838057; AUTS9; bHLHe59; CG1705; CG1705 gene product from transcript CG1705-RB; CG1705-PA; CG1705-PB; cMet; c-met; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; Hgfr; HGF-SF receptor; juvenile hormone resistance; Met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met |
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| Sensibilité du dosage | 0.08 ng/mL |
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| Type de produit | ELISA |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Symbole de gène(s) | MET |
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| Coefficient de variation intra-dosage | <10% |
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| Marqueur ou colorant | HRP |
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| État réglementaire | Research Use Only |
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| Conditions de stockage | 2°C to 8°C |
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| Heure du test | 1 hr 20 min |
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| Plage de dosage | 0.082 to 20 ng/mL |
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| Conjugué | Biotin |
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| Type d’échantillon | Supernatant |
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| Identification génétique (Entrez) | P16056 |
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| Coefficient de variation inter-dosage | <12% |
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| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
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| Quantité | 10 x 96 Tests |
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| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
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| Cible | c-Met |
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| Durée totale du dosage | 4 hr 45 min |
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