The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Caractéristiques techniques
| Marque | Invitrogen |
| Réf. B-LABO | BL-RE-094044 |
| Réf. fabricant | 18507804 |
| Numéro d’adhésion | Artemin; ARTN; Enovin; EVN; NBN; neublastin; neurotrophic factor |
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| Plage de dosage | 4.10 to 1,000 pg/mL |
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| Sensibilité du dosage | 4 pg/mL |
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| Conjugué | Biotin |
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| Type de produit | ELISA |
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| Type d’échantillon | Supernatant |
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| À utiliser avec (équipement) | Colorimetric Microplate Reader |
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| Identification génétique (Entrez) | Q5T4W7 |
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| Symbole de gène(s) | ARTN |
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| Coefficient de variation inter-dosage | <12% |
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| Coefficient de variation intra-dosage | <10% |
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| Contenus des kits | Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers |
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| Marqueur ou colorant | HRP |
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| Quantité | 10 x 96 Tests |
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| État réglementaire | Research Use Only |
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| Volume d’échantillon | Serum, 50 µL; Plasma, 50 µL; Supernatant, 50 µL |
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| Conditions de stockage | 2°C to 8°C |
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| Cible | Artemin |
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| Heure du test | 1 hr 20 min |
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| Durée totale du dosage | 4 hr 45 min |
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