PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules.
PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma.
PD-L1 binds to T cell B7-1/CD80 and PD-1.
It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells.
It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development.
PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells.
In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.
Caractéristiques techniques
Marque
R&D Systems
Réf. B-LABO
BL-RE-095984
Réf. fabricant
18712969
Type de produit
ELISA
À utiliser avec (application)
Control
À utiliser avec (équipement)
Catalog number DB7H10
Identification génétique (Entrez)
29126
Espèces hôtes
Human, Cynomolgus Monkey
Quantité
1 Ea.
Conditions de stockage
Store the unopened product at 2°C to 8°C. Do not use past expiration date.
