Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
Points forts
Cross Reactivity
Not Applicable
Formulation
1 Vial purified Protein (1 ng/ml) in 4% BSA and no preservative;
PA5-32691 detects CAV1/Caveolin in Human samples. PA5-32691 has been successfully used in Immunohistochemistry (Paraffin) procedures. PA5-32691 The immunogen is Synthetic 16 amino acid peptide from N-terminus of human CAV1/Caveolin..
Caractéristiques techniques
| Marque | Thermo Scientific |
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| Réf. B-LABO | BL-RE-097411 |
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| Réf. fabricant | 10117493 |
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| Plage de dosage | 10.2 to 400 pg/mL |
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| Sensibilité du dosage | <1 pg/mL |
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| Format du kit d’immunoessai | Colorimetric ELISA (TMB substrate) with Plates |
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| Type d’échantillon | Cell Culture Supernatant, Plasma (EDTA, Citrate, Heparin), Serum, Urine |
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| Spécificité | SIL6 |
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| Suffisant pour | ELISA standard curve with replicates |
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| Mesure | Absorbance at 450nm minus absorbance at 550nm |
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| Précision | Intra-assay CV <10%; inter-assay CV <10% |
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| Quantité | 1 Vial |
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| Volume d’échantillon | 50 μL |
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| Conditions de stockage | Store at -20°C. Avoid freeze-thaw cycles. |
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| Cible | Natural and recombinant human interleukin-6 (IL-6) |
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| Durée totale du dosage | 3 hr. |
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