This shuttle vector contains the complete ORF for the gene of interest, along with a Kozak consensus sequence for optimal translation initiation. It is inserted NotI to AscI. The gene insert is flanked with convenient multiple cloning sites which can be used to easily cut and transfer the gene cassette into your desired expression vector.
The Shrew-1/AJAP1 insert is sequence verified and the entire plasmid DNA and insert translated sequences are provided.
AJAP1 is a transmembrane protein found on the basolateral surface of epithelium.
It is presumably expressed by multiple types of epithelium and participates in cellcell adhesion.
AJAP1 is an accompanying transmembrane molecule that interacts with Ecadherin and appears to promote the internalization of E-cadherin upon growth factor stimulation.
This facilitates the dissolution of adherens junctions with an increase in cell motility.
AJAP1 is also known to complex with CD147 in nonpolar, invasive cells, suggesting that AJAP1 may play a more complex role in cell migration.
For reasearch use only. Not for use in humans.
Caractéristiques techniques
Marque
R&D Systems
Réf. B-LABO
BL-RE-099420
Réf. fabricant
18757648
Expression
<i>m</i>Ajap1
Numéro d’adhésion
NP_001092769
Concentration
10 μg at 0.2 μg/μL
Formule
cDNA is provided in 10 mM Tris-Cl, pH 8.5
Type d’insert
1252 bp
Identification génétique (Entrez)
55966
Contenu et stockage
Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Espèces
Mouse
Quantité
10 μg
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