Protein kinase inhibitor
H-7 dihydrochloride is a protein kinase inhibitor (IC50 values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 μM, respectively. H-7 shows antiviral activity against influenza A (IC50 = 10 μM)
in vitro
. H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA -stimulated interleukin 1β production.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125321 |
| Réf. fabricant | 18084052 |
| Nom chimique ou matériau | '±-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride |
| CAS | 108930-17-2 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 50 mg |
| Solubilité | Soluble to 20mM in DMSO |
| Formule moléculaire | C<sub>14</sub>H<sub>17</sub>N<sub>3</sub>O<sub>2</sub>S.2HCl |
| Poids de la formule | Observed MW: 364.29 |
