TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO -stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.
- Nom chimique ou matériau
- 2-Chloro-α,α-diphenylbenzeneacetonitrile
- CAS
- 197525-99-8
- Plage de pourcentage du dosage
- >99%
- Quantité
- 25 mg
- Formule moléculaire
- C20H14ClN
- Poids de la formule
- Observed MW: 303.78
