Potent KCa3.1 (IK) blocker
TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO -stimulated increases in rat artery membrane potential
ex vivo
. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells
in vitro
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125851 |
| Réf. fabricant | 18708666 |
| Nom chimique ou matériau | 2-Chloro-α,α-diphenylbenzeneacetonitrile |
| CAS | 197525-99-8 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>20</sub>H<sub>14</sub>ClN |
| Poids de la formule | Observed MW: 303.78 |
