Ubiquitin-proteasome and NF-κB pathway inhibitor; Inhibits proteasome and stabilizes IκB
CAS
133407-82-6
Synonyme
Z-Leu-Leu-Leu-CHO; Calpain inhibitor IV-2
Quantité
1 mg
Formule moléculaire
C26H41N3O5
Pureté
≥98%
Marque
STEMCELL Technologies
(S)-MG132 is a reversible, cell-permeable inhibitor of proteasome activity (IC50 = 100 nM; Kisselev & Goldberg) and calpain (IC50 = 1.2 μM; Tsubuki et al.) The ubiquitin-proteasome pathway selectively degrades intracellular proteins, thereby clearing damaged or misfolded proteins, and regulating the availability of key proteins involved in the control of inflammatory processes and cell cycle regulation
(S)-MG132 suppresses NF-κB activation by preventing IκB degradation (IC50 = 3 μM; Arlt et al.), Palombella et al.), Ortiz-Lazareno et al.)
Blocks apoptosis triggered by DNA damage in HeLa cells (Zhang et al.)
Inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis (Arlt et al.)
Cytotoxic effects on a variety of human cancer cell lines (Banerjee & Liefshitz)
Inhibits growth of mouse melanoma (B16) and human ocular melanoma (IPC227F) cell lines (Vivier et al.)
