VaLproic Acid (VPA) is a short-chain fatty acid that acts as an epigenetic modifier by inhibiting Histone Deacetylases (HDACs) with IC50 values ranging from 0.4 - 3 mM
VPA can also increase γaminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism
Other effects include depletion of cellular inositol by inhibiting myo-inositol-1-phosphate synthase
(Gottlicher et al.), Khan et al.), Phiel et al.), Rosenberg)
Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Tranylcypromine, 3-Deazaneplanocin A, and E-616452 (Hou et al.)
Increases the reprogramming efficiency of mouse embryonic fibroblasts to iPS cells (Huangfu et al. 2008a)
Promotes reprogramming of human fibroblasts to iPS cells using only 2 factors, OCT4 and SOX2 (Huangfu et al. 2008b)
Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.)
Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Chaurasia et al.)
Promotes the proliferation and self-renewal of human and mouse hematopoietic progenitor cells (Bug et al.), De Felice et al.)
Promotes differentiation of neurons and suppresses differentiation of astrocytes and oligodendrocytes from rat neural progenitor cells (Hsieh et al.), Jung et al.)
Promotes osteogenic differentiation of human mesenchymal stem cells (Cho et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126403
Réf. fabricant
16313287
CAS
1069-66-5
Synonyme
2-Propylvaleric acid; Sodium valproate; VPA
Quantité
500 mg
Formule moléculaire
C<sub>8</sub>H<sub>15</sub>O<sub>2</sub> · Na
Pureté
≥95%
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