Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC), including Group A and Group B isoforms (Blumberg)
PMA activates PKC isoforms through the binding of the C1 domain (Hurley et al.) PMA can also activate certain mitogen-activated protein (MAP) kinase pathways through PKC (Adams & Parker)
Stimulates cardiac differentiation of mesenchymal stem cells (Seo et al.)
Promotes hematopoietic differentiation (Clemens et al.)
Stimulates differentiation of IL-15-stimulated lamina propria CD4+ T cells into CXCR5+CD4+ cells when used together with ionomicin (Sarra et al.)
In combination with AS101, it shows anti-leukemic activity and stimulates human leukemia cell lines to differentiate into macrophage-like cells (Glesne & Huberman; Hayun et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126416
Réf. fabricant
17160312
CAS
16561-29-8
Synonyme
12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA
Quantité
1 mg
Formule moléculaire
C<sub>36</sub>H<sub>56</sub>O<sub>8</sub>
Pureté
≥98%
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