Tyrosine kinase inhibitor; Inhibits LCK, FYN, HCK, and SRC
CAS
172889-26-8
Synonyme
AGL 1872; EI 275
Quantité
1 mg
Formule moléculaire
C16H19N5
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
PP1 is a reversible inhibitor of the SRC family of tyrosine kinases
It inhibits LCK, FYN, HCK and SRC with IC50 values of 5, 6, 20 and 170 nM, respectively (Hanke et al.) It is relatively selective for SRC family kinases versus other kinases, inhibiting epidermal growth factor receptor (EGFR), janus-activated kinase 2 (JAK2) and zeta-chain-associated protein kinase 70 (ZAP70) with IC50 values of 0.25, > 50, and > 100 μM, respectively, and KIT, platelet-derived growth factor receptor (PDGFR), and RET tyrosine kinase in the 75 - 100 nM range (Carlomagno et al.; Tatton et al.; Waltenberger et al.; Hanke et al.) PP1 also blocks TGF-β-mediated cellular responses by directly inhibiting type I TGF-β receptors (IC50 = 50 nM; Ungefroren et al.; Maeda et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126420
Réf. fabricant
17160172
CAS
172889-26-8
Synonyme
AGL 1872; EI 275
Quantité
1 mg
Formule moléculaire
C<sub>16</sub>H<sub>19</sub>N<sub>5</sub>
Pureté
≥98%
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