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STEMCELL Technologies BIO-Acetoxime | B-LABO France
STEMCELL Technologies BIO-Acetoxime
Réf. : BL-RE-126422Réf. fabricant : 17170202 1 mg
162,00 € HT
WNT pathway activator; Inhibits GSK3
CAS
740841-15-0
Synonyme
6-Bromoindirubin-3’-acetoxime; BIA; GSK-3 inhibitor X
Quantité
1 mg
Formule moléculaire
C18H12BrN3O3
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
BIO-Acetoxime is an analog of the GSK3 inhibitor BIO (Catalog #72032)
It potently inhibits GSK3α and GSK3β (IC50 = 10 nM), and less potently inhibits cyclin-dependent kinases Cdk5/p25, Cdk2/A, and Cdk1/B (IC50 = 2.4, 4.3, and 63 μM, respectively; Meijer et al.; Polychronopoulos et al.) By inhibiting GSK3β, BIO-Acetoxime blocks β-catenin phosphorylation and degradation, thereby allowing it to activate transcription of WNT pathway-controlled genes (Meijer et al.)
Inhibits CD8+ effector T cell differentiation (Zhou et al.)
Suppresses viral gene expression and protects oral epithelial cells from herpes simplex virus-1 infection (Hsu & Hung)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126422
Réf. fabricant
17170202
CAS
740841-15-0
Synonyme
6-Bromoindirubin-3’-acetoxime; BIA; GSK-3 inhibitor X
