BET family inhibitor; Inhibits BRD2, BRD3, and BRD4
CAS
1300031-49-5
Synonyme
GSK1210151A
Quantité
10 mg
Formule moléculaire
C23H21N5O3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
I-BET151 is an inhibitor of bromodomain and extra terminal (BET) family proteins
BET proteins recognize acetylated lysine residues via their 2 bromodomains (Gallenkamp et al.) I-BET151 inhibits BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 μM, respectively (Kline et al.; Vidler et al.; Hewings et al.; Dawson et al. 2012)
Enhances reprogramming of mouse fibroblasts to neurons, in combination with ISX-9, Forskolin, and CHIR99021 (Li et al.)
Induces early cell cycle arrest and apoptosis in human and mouse MLL-fusion leukemia cell lines by blocking transcription of key genes including BCL2, C-MYC, and CDK6 (Dawson et al.) 2011)
