EC23 is a retinoic acid receptor (RAR) agonist with pan-RAR activity (EC50: RARα 41 nM, RARβ 0.5 nM, RARγ 0.4 nM), while having no appreciable activity for retinoid X receptors (RXR; EC50> 10μM for all; Gambone et al.) It is a photostable synthetic analog of all-trans retinoic acid (ATRA; Christie et al. 2008)
EC23 also weakly activates aryl hydrocarbon receptor (Gambone et al.)
Induces neural differentiation of human pluripotent stem cells, similarly to ATRA (Christie et al. 2010; Clemens et al.)
Induces neuronal differentiation of human fetal neural progenitor cell line ReNcell 197VM (Christie et al. 2010)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126431
Réf. fabricant
17140172
CAS
104561-41-3
Synonyme
AGN 190205; BASF 46928
Quantité
1 mg
Formule moléculaire
C<sub>23</sub>H<sub>24</sub>O<sub>2</sub>
Pureté
≥98%
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