Inducer of definitive endoderm 1 (IDE1) induces differentiation of mouse or human pluripotent stem cells (PSCs) by activating SMAD2 phosphorylation and NODAL expression (Borowiak et al.) At EC50 = 125 nM, SOX17 expression was induced in mouse ES cells
Induces differentiation of mouse or human ES cells to definitive endoderm in the absence of Activin A, NODAL, or feeder cells (Borowiak et al.)
