EX527 is a cell-permeable, selective inhibitor of mammalian sirtuin 1 (SIRT1; IC50 = 98 nM) over SIRT2 and SIRT3 and has no effect on other histone deacetylases (HDACs; Nayagam et al.) SIRT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase with roles in energy metabolism and inflammation
Studies have shown that EX527 inhibits sirtuins by forming a trimeric sirtuin complex with an NAD+-derived coproduct (Gertz M et al.)
Increases the production of oligodendrocytes from differentiating neural stem cells and neural progenitor cells in vitro (Rafalski et al.)
Restores the microvascular response during the hypoinflammatory phase in a mouse model of sepsis, and enhances the systemic innate immune response (Vachharajani et al.)
Delays cyst growth in kidneys of PKD1 knockout mouse models (Zhou et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126471
Réf. fabricant
17180252
CAS
49843-98-3
Synonyme
Selisistat
Quantité
10 mg
Formule moléculaire
C<sub>13</sub>H<sub>13</sub>ClN<sub>2</sub>O
Pureté
≥98%
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