Shz-1 is a cell-permeable, sulphonyl hydrazone (Shz) compound that activates cardiac differentiation through induction of genes such as Nkx2.5 (Sadek et al.)
Promotes cardiac differentiation in mouse induced pluripotent stem cells (Quattrocelli et al.)
Induces cardiac differentiation of human mobilized peripheral blood mononuclear cells; these cells enhance myocardial regenerative repair when injected in a cryo-injured rat heart model (Sadek et al.)