ARRY-142886; Cl-1040; NSC 741O78; Selumetinib; G 00039805
Quantité
50 mg
Formule moléculaire
C17H15BrClFN4O3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
AZD6244 is a potent, highly selective inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM; Yeh et al.; Davis et al.) It is a tight-binding noncompetitive inhibitor that does not bind in the ATP binding pocket of MEK (Huynh et al.) It also shows micromolar binding to epidermal growth factor receptor (EGFR; Davis et al.)
Inhibits growth of several tumor cell lines but not normal fibroblast lines, and inhibits tumor growth in a colorectal xenograft tumor model (Yeh et al.)
Inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, especially those containing BRAF or RAS mutations (Davies et al.)
Inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing RAF and RAS mutations, respectively (Garon et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126505
Réf. fabricant
17190152
CAS
606143-52-6
Synonyme
ARRY-142886; Cl-1040; NSC 741O78; Selumetinib; G 00039805
