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STEMCELL Technologies IWR-1-endo | B-LABO France
STEMCELL Technologies IWR-1-endo
Réf. : BL-RE-126531Réf. fabricant : 17100092 5 mg
132,30 € HT
WNT pathway inhibitor; AXIN2 stabilizer
CAS
1127442-82-3
Quantité
5 mg
Formule moléculaire
C25H19N3O3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
IWR-1-endo potently inhibits WNT signaling by blocking a cell-based WNT/β-catenin pathway reporter response with an IC50 value of 180 nM (Chen et al.) It inhibits WNT-induced accumulation of β-catenin, through stabilization of the destruction complex member AXIN2 (Chen et al.)
Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al.) DIFFERENTIATION
Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al.; Willems et al.)
Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al.)
