Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ)
When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation (Johnson et al.)
Promotes differentiation of human bone marrow mesenchymal stem cells into chondrocytes (Johnson et al.; Zhang et al.)
Promotes cartilage formation/repair in mouse models of osteoarthritis or when injected into mouse tendon-bone junctions (Johnson et al.; Zhang et al.)
Promotes type-I collagen synthesis in human dermal fibroblasts in vitro and in the dermis of mice through activation of the SMAD4/SMAD5 pathway (Wang et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126573
Réf. fabricant
17120092
CAS
4727-31-5
Quantité
5 mg
Formule moléculaire
C<sub>20</sub>H<sub>15</sub>NO<sub>3</sub>
Pureté
≥98%
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