Tamoxifen is a selective estrogen receptor modulator (SERM), with tissue-specific antagonistic or agonistic effects
Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription
Tamoxifen is commonly used to activate Cre-ER in transgenic conditional models
Used in transgenic models to induce Cre-mediated recombination in conjunction with Cre-ER, a fusion protein consisting of Cre recombinase and a mutant form of the estrogen receptor hormone-binding domain that specifically binds tamoxifen but not estrogen (Feil et al.; Zhang et al.)
Inhibits growth in the human breast cancer cell line, MCF-7 (Katzenellenbogen et al.)
Antagonist of estrogen receptor action in breast tissue and breast cancer cells (Abe et al.; Horwitz et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126601
Réf. fabricant
17150102
CAS
10540-29-1
Synonyme
trans-Tamoxifen
Quantité
5 g
Formule moléculaire
C<sub>26</sub>H<sub>29</sub>NO
Pureté
≥95%
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