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STEMCELL Technologies Geldanamycin | B-LABO France
STEMCELL Technologies Geldanamycin
Réf. : BL-RE-126623Réf. fabricant : 17140312 1 mg
137,70 € HT
Inhibits Hsp90
CAS
30562-34-6
Synonyme
NSC 122750
Quantité
1 mg
Formule moléculaire
C29H40N2O9
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.) It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 μM; Roe et al.) Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90
This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.)
Inhibits growth of 60 human tumor cell lines (Supko et al.)
Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.)
Inhibits replication of HSV-1 and HSV-2 (Li et al.)
