QNZ is a quinazoline derivative that inhibits nuclear factor (NF)-κB activation (IC50 = 11 nM in human Jurkat T lymphocyte cells)
NF-κB enhances the transcription of pro-inflammatory cytokines, and QNZ inhibits lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF)-α production in mouse splenocytes (IC50 = 7 nM;Tobe et al.), as well as CXCL1-mediated pro-inflammatory increase in potassium currents in adult rat neurons (Yang et al)
It does not inhibit kinases in a standard screen (Wu et al.)
Neuroprotective in a glutamate toxicity assay using YAC128 medium spiny neuron cultures (Wu et al.)
Blocks amyloid precursor protein release in human SH-SY5Y neuroblastoma cells caused by muscarinic receptor activation (Choi et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126627
Réf. fabricant
17120212
CAS
545380-34-5
Synonyme
CAY10470
Quantité
1 mg
Formule moléculaire
C<sub>22</sub>H<sub>20</sub>N<sub>4</sub>O
Pureté
≥98%
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