CD437 is the prototypical adamantyl arotinoid of the retinoid-related molecule family that acts as a selective agonist of retinoic acid receptor (RAR)γ (Kd = 6.5 μM, 2.5 μM, and 77 nM for RARα, β, and γ, respectively; Bernard et al.; Pérez-Rodríguez et al.)
Increases speed and number of pre-induced pluripotent stem (iPS) cell colonies generated from mouse embryonic fibroblasts (MEFs) transfected with Oct4, Sox2, c-Myc, and Klf4 (Wang et al.)
Induces cell cycle arrest and apoptosis in a variety of cancer cells (Fontana and Rishi; Jin et al.; Li et al.; Valli et al.)
Decreases mRNA expression of squamous differentiation markers cytokeratin 1, involucrin, and SPR1 in the human head and neck squamous cell carcinoma cell line, UMSCC22B (Sun et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126643
Réf. fabricant
17170112
CAS
125316-60-1
Synonyme
AHPN
Quantité
25 mg
Formule moléculaire
C<sub>27</sub>H<sub>26</sub>O<sub>3</sub>
Pureté
≥95%
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