Epigenetic modifier; Inactivates methylguanine DNA methyltransferase (MGMT)
CAS
19916-73-5
Synonyme
NSC 637037
Quantité
50 mg
Formule moléculaire
C12H11N5O
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
O6-Benzylguanine is an efficient irreversible inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT)
AGT directly removes alkyl groups located on the O6-position of guanine from DNA, thereby restoring DNA integrity
O6-Benzylguanine is an antineoplastic agent that can be used to investigate the role of AGT in carcinogenesis and mutagenesis (Pegg 2011; Dolan et al.)
Enhances the activity of alkylating agents (nitrosourea, temozolomide, and cyclophosphamide) in malignant glioma xenografts growing in athymic nude mice (Pegg 1990)
Sensitizes CD34+ hematopoietic progenitors and a breast cancer cell line to bis-chloroethylnitrosourea (BCNU; Gerson et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126654
Réf. fabricant
17140272
CAS
19916-73-5
Synonyme
NSC 637037
Quantité
50 mg
Formule moléculaire
C<sub>12</sub>H<sub>11</sub>N<sub>5</sub>O
Pureté
≥98%
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