Paclitaxel is a diterpene alkaloid originally isolated from the bark of the Pacific Yew tree (Taxus brevifolia)
It binds to and stabilizes microtubules, preventing their reorganization during cell division, which leads to cell cycle arrest
Paclitaxel has antitumorigenic properties and has been used as a chemotherapeutic compound (Rowinsky et al.) Many pathways have been implicated in Paclitaxel-induced apoptosis, including c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38 mitogen-activated protein kinase (MAPK), and protein kinase A (PKA; Wang et al.; Reshkin et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126671
Réf. fabricant
17160202
CAS
33069-62-4
Synonyme
NSC 125973
Quantité
100 mg
Formule moléculaire
C<sub>47</sub>H<sub>51</sub>NO<sub>14</sub>
Pureté
≥98%
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