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STEMCELL Technologies (-)-Blebbistatin | B-LABO France
STEMCELL Technologies (-)-Blebbistatin
Réf. : BL-RE-126689Réf. fabricant : 17150062 5 mg
364,50 € HT
Non-muscle myosin II (NM II) ATPase inhibitor
CAS
856925-71-8
Quantité
5 mg
Formule moléculaire
C18H16N2O2
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
(-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases (Kovács et al.; Straight et al.) It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50 = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM) (Limouze et al.)
Increases human pluripotent stem cell (hPSC) survival and cloning efficiency after dissociation to single cells, downstream of ROCK inhibition (Chen et al.; Ohgushi et al.; Walker et al.; Xu et al.)
Enables hPSC to be cultured on microcarriers without surface coating (Chen et al.)
Inhibits differentiation of human mesenchymal stem cells (McBeath et al.; Engler et al.)
