PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3
CAS
612847-09-3
Synonyme
AKTi-1/2; AKT 1/2 inhibitor
Quantité
10 mg
Formule moléculaire
C34H29N7O
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC50 values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126703
Réf. fabricant
17120152
CAS
612847-09-3
Synonyme
AKTi-1/2; AKT 1/2 inhibitor
Quantité
10 mg
Formule moléculaire
C<sub>34</sub>H<sub>29</sub>N<sub>7</sub>O
Pureté
≥98%
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