DMH1 (dorsomorphin homolog 1) is a selective inhibitor of activin receptor-like kinase 2 (ALK2; IC50 = 13 - 108 nM), a type I bone morphogenetic protein (BMP) receptor (Hao et al.; Mohedas et al.) DMH1 exhibits no detectable inhibition of ALK4, ALK5, AMPK, KDR (VEGFR2), or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations (Hao et al.; Mohedas et al.)
