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STEMCELL Technologies LY411575 | B-LABO France
STEMCELL Technologies LY411575
Réf. : BL-RE-126719Réf. fabricant : 17170122 5 mg
151,20 € HT
Notch pathway inhibitor; Inhibits γ-secretase
CAS
209984-57-6
Quantité
5 mg
Formule moléculaire
C26H23F2N3O4
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that blocks Notch activation in vitro at 500 μM (Curry et al.; Czirr et al.) via γ-Secretase inhibition
Notch is a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis
Promotes neuronal differentiation of neural progenitor cells derived from mouse embryonic stem (ES) cells (Abranches et al.; Aranha et al.)
Promotes goblet cell differentiation in mouse intestine and cultured colonic organoids (Okamoto et al.; Yui et al.)
Induces hair cell differentiation from inner ear stem cells in vitro, and transdifferentiation of supporting cells into hair cells in vivo (Bramhall et al.; Mizutari et al.)
Causes premature differentiation of Her4-positive progenitors into neurons in zebrafish (Dirian et al.)
Induces apoptosis in primary and immortalized Karposi's sarcoma cells (Curry et al.)
