(Z)-Guggulsterone is a plant steroid found in the resin of the guggul plant Commiphora mukul that acts as a selective antagonist of farnesoid X receptor (FXR; Cui et al.) It decreases chenodeoxycholic acid-induced FXR activation (IC50 = 10 μM) in the presence of 100 μM chenodeoxycholic acid (Cui et al.; Urizar et al.)
Induces differentiation of human pluripotent stem cell-derived neural stem cells into dopaminergic neurons (Gonzalez et al.)
Decreases hepatic low-density lipoprotein cholesterol and triglyceride levels in rodents fed with a high-cholesterol diet (Urizar et al.)
Regulates growth and metastasis of tumor cells in human multiple myeloma cells by the expression of STAT3-regulated antiapoptotic (Bcl-2, Bcl-xL, and Mcl-1), proliferative (cyclin D1), and angiogenic (VEGF) gene products (Ahn et al.)
Inhibits tube formation in human umbilical vein endothelial cells (HUVECs) and migration in HUVECs or a human prostate cancer cell line (Xiao et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-126723
Réf. fabricant
17179971
CAS
39025-23-5
Quantité
10 mg
Formule moléculaire
C<sub>21</sub>H<sub>28</sub>O<sub>2</sub>
Pureté
≥98%
Une question, une configuration particulière ? Contactez-nous pour un devis.
