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STEMCELL Technologies (±)-Nutlin-3 | B-LABO France
STEMCELL Technologies (±)-Nutlin-3
Réf. : BL-RE-151709Réf. fabricant : 17120272 1 mg
71,55 € HT
p53 pathway activator; Inhibits MDM2
CAS
548472-68-0
Quantité
1 mg
Formule moléculaire
C30H30Cl2N4O4
Pureté
>98%
Marque
STEMCELL Technologies
Caractéristiques principales
(±)-Nutlin-3 is a small-imidazoline-based mouse double minute 2 (MDM2) protein antagonist which disrupts MDM2-p53 interaction (IC50 = 0.09 μM; Vassilev et al.) MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability
By disrupting this interaction, (±)-Nutlin-3 therefore promotes the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53 (Vassilev et al.), Gu et al.)
