NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
CAS
503468-95-9
Synonyme
KU57788
Quantité
10 mg
Formule moléculaire
C25H19NO3S
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
It is highly selective for DNA-PK, with an IC50 of 14 nM (Leahy et al.)
Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.)
Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151732
Réf. fabricant
17160322
CAS
503468-95-9
Synonyme
KU57788
Quantité
10 mg
Formule moléculaire
C<sub>25</sub>H<sub>19</sub>NO<sub>3</sub>S
Pureté
≥98%
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