cAMP pathway activator; Inhibits type 4 cyclic nucleotide phosphodiesterases (PDE4)
CAS
61413-54-5
Synonyme
SB 95952; ZK 62711
Quantité
25 mg
Formule moléculaire
C16H21NO3
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
Rolipram is a cell-permeable, selective inhibitor of Type 4 cyclic nucleotide phosphodiesterases (PDE4), which mediate cyclic AMP (cAMP) degradation
Rolipram preferably inhibits PDE4 isoform A (IC50 = 3 nM) over other isoforms such as B and D (IC50 = 130 and 240 nM respectively; MacKenzie & Houslay)
It inhibits interferon (IFN)-γ stimulated phosphorylation of p38 mitogen-activated protein (MAP) kinase through PDE4B and/or PDE4D isoform inhibition (MacKenzie & Houslay)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-151750
Réf. fabricant
17170212
CAS
61413-54-5
Synonyme
SB 95952; ZK 62711
Quantité
25 mg
Formule moléculaire
C<sub>16</sub>H<sub>21</sub>NO<sub>3</sub>
Pureté
≥98%
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