ME0328 is a cell-permeable and selective inhibitor of poly(ADP-ribose) polymerase 3 (PARP-3; IC50 = 0.89 μM; Lindgren et al.) PARP-3 is required for stabilization of the mitotic spindle and crucial for mitotic progression (Sharif-Askari et al.)
Enhances vinorelbine-induced microtubule destabilization, leading to cell cycle arrest and apoptosis in breast cancer cells (Sharif-Askari et al.)
