BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs)
RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.) BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.)
Affects development of bronchial tubule formation in mice (Chazaud et al.)
Inhibits activation of immature dendritic cells (Geissmann et al.)
Inhibits differentiation of leukemic blasts (Kamashev et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-158217
Réf. fabricant
17140302
CAS
215030-90-3
Synonyme
BMS 204493
Quantité
1 mg
Formule moléculaire
C<sub>29</sub>H<sub>24</sub>O<sub>2</sub>
Pureté
≥98%
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