GANT61 is a hexahydropyrimidine derivative which selectively inhibits GLI transcription factors in the Hedgehog signaling pathway
GANT61 acts downstream of Smoothened to inhibit both GLI1- and GLI2-mediated transcription (IC50 = 5 μM in a GLI-transfected cell line) by preventing their DNA binding (Lauth et al.)
Inhibits in vitro proliferation of cancer cell lines (PANC1 and 22Rv1) with elevated GLI1 levels, and prevents the development of 22Rv1 tumors in mice (Lauth et al.)
Inhibits pancreatic cancer stem cell growth in vitro and in mouse xenograft model (Fu et al.)
Induces cell death of primitive neuroectodermal tumor cell line in a caspase-independent manner by inhibiting DNA replication (Matsumoto et al.)
Causes apoptosis in myeloid leukemia cells and in some cell lines is more effective when combined with rapamycin (Pan et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-158219
Réf. fabricant
17150262
CAS
500579-04-4
Synonyme
NSC 136476
Quantité
10 mg
Formule moléculaire
C<sub>27</sub>H<sub>35</sub>N<sub>5</sub>
Pureté
≥98%
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