Activates nuclear factor erythroid 2-related factor 2 (Nrf2) protein
CAS
3133-16-2
Synonyme
2-methylene-butanedioic acid; 4-octyl ester
Quantité
50 mg
Formule moléculaire
C13H22O4
Pureté
≥98%
Marque
STEMCELL Technologies
Caractéristiques principales
4-Octyl Itaconate is a cell-permeable derivative of itaconate, a metabolite produced during the Krebs cycle
It is a potent activator of nuclear factor erythroid 2-related factor 2 (Nrf2) via alkylation of the inhibitor of Nrf2 (Keap1), thereby promoting Nrf2-mediated transcriptional activation and downstream anti-oxidant and anti-inflammatory properties (Mills et al.; Tang et al.)
The itaconate pathway (IRG1-itaconate-SDH) plays a pivotal role in up-regulating tolerance and inhibiting the induction of trained immunity (Domínguez-Andrés et al.)
Counteracts the proinflammatory signals of succinate by inhibiting succinate dehydrogenase (SDH) and activating Nrf2 to limit inflammation in mouse and human macrophages (Lampropoulou et al.; Mills et al.)
Activates Nrf2 signaling in human macrophages, which has been shown to inhibit the production of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 (Tang et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-158224
Réf. fabricant
17160342
CAS
3133-16-2
Synonyme
2-methylene-butanedioic acid; 4-octyl ester
Quantité
50 mg
Formule moléculaire
C<sub>13</sub>H<sub>22</sub>O<sub>4</sub>
Pureté
≥98%
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