GSA 10 is an agonist of Smoothened (SMO), a cell surface receptor and mediator of the hedgehog signaling pathway
It is a quinolinecarboxamide derivative that binds in a distinct binding pocket from cyclopamine
GSA10 is active at an EC50 of 1.2 μM in an alkaline phosphatase-based mouse mesenchymal cell line (C3H10T1/2) differentiation assay (Gorojankina et al.)
Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts (Gorojankina et al.)
