Generated SQL Query: SELECT b.id, b.name, b.categoryId, b.subCategoryId FROM brand b GROUP BY b.id LIMIT 15
STEMCELL Technologies RS-1

STEMCELL Technologies RS-1

Ref: 17170322
182.25€ - 344.25€

HDR pathway enhancer; Enhances RAD51

CAS:
312756-74-4
Quantité:
10 mg
Formule moléculaire:
C<sub>20</sub>H<sub>16</sub>Br<sub>2</sub>N<sub>2</sub>O<sub>3</sub>S
Pureté:
&ge;95%
Brand
STEMCELL Technologies

  • RS-1 is an enhancer of RAD51, an enzyme that assists in the homology-directed repair (HDR) pathway of DNA double-strand breaks, and is reported to function by stabilizing the active form of RAD51 and by enhancing recombinogenic activity of the enzyme (Jayathilaka et al.) Via this mechanism, RS-1 can stimulate HDR, thereby enhancing precise HDR-dependent CRISPR-Cas9 genome editing in some cell lines (Pinder et al.; Song et al.)
  • Promotes HDR, which is reported to enhance knock-in efficiency of CRISPR-Cas9 genome editing (Pinder et al.; Song et al.; however, these effects are cell type-specific and context-dependent (Xie et al.; Zhang et al.)
  • Stimulates the DNA-binding activity of RAD51 to promote cancer cell death and induce anti-tumor responses in a mouse xenograft tumor model (Mason et al.)

CAS : 312756-74-4


Quantité : 10 mg


Formule moléculaire : C20H16Br2N2O3S


Pureté : ≥95%