NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)
CAS
154447-35-5
Synonyme
LY293646; DNA-PK Inhibitor II
Quantité
5 mg
Formule moléculaire
C17H15NO3
Pureté
≥95%
Marque
STEMCELL Technologies
Caractéristiques principales
NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.) NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.)
Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.)
Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-160899
Réf. fabricant
17120342
CAS
154447-35-5
Synonyme
LY293646; DNA-PK Inhibitor II
Quantité
5 mg
Formule moléculaire
C<sub>17</sub>H<sub>15</sub>NO<sub>3</sub>
Pureté
≥95%
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