Anacardic Acid is a 6-alkyl salicyclic acid that inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF; IC50 values of 8.5 and 5 μM, respectively; Balasubramanyam et al.) Anacardic Acid inhibits HAT-dependent transcription and protein SUMOylation (Cui et al.; Fukuda et al.) In addition, Anacardic Acid is an activator of Aurora kinase A-mediated phosphorylation of Histone H3 (Kishore et al.) At higher concentrations (25 μM), Anacardic Acid suppresses NF-κB activation and inhibits IκB-α phosphorylation (Sung et al.)
Caractéristiques techniques
Marque
STEMCELL Technologies
Réf. B-LABO
BL-RE-162436
Réf. fabricant
17180182
CAS
16611-84-0
Quantité
5 mg
Formule moléculaire
C<sub>22</sub>H<sub>36</sub>O<sub>3</sub>
Pureté
≥98%
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