"/> Tocris Bioscience™ MS 28 | B-LABO France

Tocris Bioscience™ MS 28

Name: Tocris Bioscience™ MS 28
Brand: Tocris Bioscience
SKU: 30067464
Price: 412.52 EUR
Availability: InStock

Réf. : BL-RE-165678Réf. fabricant : 30067464 5 mg

412,52 € HT

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC™)

Nom chimique ou matériau: (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS: 2229974-73-4
Quantité: 5 mg
Cible: Active Degraders
Formule moléculaire: C₅₃H₆₇N₁₁O₇S
Marque: Tocris Bioscience

MS 28 is a cyclinD1 Degrader (PROTAC™) (DC50 = 950 nM; Dmax = 90%

in vitro

). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-165678
Réf. fabricant	30067464
Nom chimique ou matériau	(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS	2229974-73-4
Quantité	5 mg
Cible	Active Degraders
Formule moléculaire	C<sub>53</sub>H<sub>67</sub>N<sub>11</sub>O<sub>7</sub>S
Pureté	0.98

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Tocris Bioscience™ MS 28

Caractéristiques techniques

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