"/> Tocris Bioscience™ MS 28 | B-LABO France

Tocris Bioscience™ MS 28

Réf. : BL-RE-165678Réf. fabricant : 30067464 5 mg
412,52 € HT

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC™)

Nom chimique ou matériau
(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS
2229974-73-4
Quantité
5 mg
Cible
Active Degraders
Formule moléculaire
C53H67N11O7S
Marque
Tocris Bioscience

MS 28 is a cyclinD1 Degrader (PROTAC™) (DC50 = 950 nM; Dmax = 90%

in vitro

). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-165678
Réf. fabricant30067464
Nom chimique ou matériau(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS2229974-73-4
Quantité5 mg
CibleActive Degraders
Formule moléculaireC<sub>53</sub>H<sub>67</sub>N<sub>11</sub>O<sub>7</sub>S
Pureté0.98
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