Potent and selective amylin antagonist
AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases
in vitro
. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-053717 |
| Réf. fabricant | 18034502 |
| Pureté | 0.95 |
| Contenu et stockage | Store at -20°C |
| Quantité | 500 μg |
