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Tocris Bioscience™ RQ 00203078

Name: Tocris Bioscience™ RQ 00203078
Brand: Tocris Bioscience
SKU: 18778218
Price: 207.34 EUR
Availability: InStock

Réf. : BL-RE-084270Réf. fabricant : 18778218 10 mg

207,34 € HT

Potent and selective TRPM8 antagonist; orally active

Pureté: >98%
Description: RQ 00203078
Poids moléculaire: 554.85
Type de produit: RQ 00203078
Quantité: 10 mg
Marque: Tocris Bioscience

RQ 00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion

in vitro

. Also attenuates icilin -induced wet dog shakes in rats. Orally active.